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Associations of habitual physical activity and carotid-femoral pulse wave velocity; a systematic review and meta-analysis of observational studies

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  • Rebecca Lear
  • Brad Metcalf
  • Gemma Brailey
  • Michael Nunns
  • Bert Bond
  • Melvyn Hillsdon
  • Richard Pulsford

Abstract

The aim of this review was to understand the association between habitual physical activity (hPA) and carotid-femoral pulse wave velocity (cfPWV) in an ostensibly healthy adult population. Searches were performed in MEDLINE Web of Science, SPORTDiscus and CINAHL databases published up to 01/01/2022 (PROSPERO, Registration No: CRD42017067159). Observational English-language studies assessing the relationship between cfPWV and hPA (measured via self-report or device-based measures) were considered for inclusion in a narrative synthesis. Studies were excluded if studying specific disease. Studies were further included in pooled analyses where a standardised association statistic for continuous hPA and cfPWV was available. 29 studies were included in narrative synthesis, of which 18 studies provided sufficient data for pooled analyses, totalling 15,573 participants. A weak, significant, negative correlation between hPA and cfPWV was observed; partial r = -0.08 95%CI [-0.15, -0.01]; P = 0.045. Heterogeneity was high (I2 = 94.5% P

Suggested Citation

  • Rebecca Lear & Brad Metcalf & Gemma Brailey & Michael Nunns & Bert Bond & Melvyn Hillsdon & Richard Pulsford, 2023. "Associations of habitual physical activity and carotid-femoral pulse wave velocity; a systematic review and meta-analysis of observational studies," PLOS ONE, Public Library of Science, vol. 18(4), pages 1-20, April.
    • Handle: RePEc:plo:pone00:0284164
    DOI: 10.1371/journal.pone.0284164
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