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The histological analysis of the coronary medial thickness: Implications for percutaneous coronary intervention

Author

Listed:
  • Takao Konishi
  • Saikat Kumar B Ghosh
  • Yu Sato
  • Rika Kawakami
  • Kenji Kawai
  • Aimee E Vozenilek
  • Weili Xu
  • Arielle Bellissard
  • Robert Giasolli
  • Diljon Chahal
  • Renu Virmani
  • Aloke V Finn

Abstract

Background: A deeper understanding of coronary medial thickness is important for coronary intervention because media thickness can limit the safety and effectiveness of interventional techniques. However, there is a paucity of detailed data on human coronary medial thickness so far. Materials and methods: We investigated the thickness of the media by histologic analysis. A total of 230 sections from 10 individuals from the CVPath autopsy registry who died from non-coronary deaths were evaluated. We performed pathological analysis on 13 segments of the following primary vessels from coronary arteries: the left main trunk, proximal left anterior descending artery (LAD), mid LAD, distal LAD, proximal left circumflex artery (LCX), mid LCX, distal LCX, proximal right coronary artery (RCA), mid RCA, and the distal RCA. The following side branches were also evaluated: diagonal, obtuse margin, and posterior descending artery branches. Results: The average age of the studied individuals was 60.4±12.3 years. The median medial thickness for all sections was 0.202 (0.149–0.263) mm. The median medial thickness of the main branches was significantly higher compared to that of the side branches (p

Suggested Citation

  • Takao Konishi & Saikat Kumar B Ghosh & Yu Sato & Rika Kawakami & Kenji Kawai & Aimee E Vozenilek & Weili Xu & Arielle Bellissard & Robert Giasolli & Diljon Chahal & Renu Virmani & Aloke V Finn, 2023. "The histological analysis of the coronary medial thickness: Implications for percutaneous coronary intervention," PLOS ONE, Public Library of Science, vol. 18(3), pages 1-11, March.
    • Handle: RePEc:plo:pone00:0283840
    DOI: 10.1371/journal.pone.0283840
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