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Sex-based differences in long-term outcomes after stroke: A meta-analysis

Author

Listed:
  • Xiumei Guo
  • Yu Xiong
  • Xinyue Huang
  • Zhigang Pan
  • Xiaodong Kang
  • Chunhui Chen
  • Jianfeng Zhou
  • Hanlin Zheng
  • Yuping Chen
  • Weipeng Hu
  • Lingxing Wang
  • Feng Zheng

Abstract

Background: There is limited data on sex-related disparities in the long-term outcomes after stroke. We aim to investigate whether there are sex-based differences in long-term outcomes using pooled data. Methods: Three databases (PubMed, Embase, and Cochrane Library) were systematically searched from inception to July 2022. This meta-analysis was performed in accordance with the recommendations and guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The modified Newcastle-Ottawa scale was used to assess the risk of bias. In addition, a random-effects model was used. Results: Twenty-two cohort studies with 84538 patients were included. There were 50.2% men and 49.8% women. Women had a higher mortality at 1 (odds ration [OR], 0.82; 95% confidence interval [CI][0.69, 0.99], P = 0.03) and 10 (OR 0.72, 95% CI[0.65, 0.79], P

Suggested Citation

  • Xiumei Guo & Yu Xiong & Xinyue Huang & Zhigang Pan & Xiaodong Kang & Chunhui Chen & Jianfeng Zhou & Hanlin Zheng & Yuping Chen & Weipeng Hu & Lingxing Wang & Feng Zheng, 2023. "Sex-based differences in long-term outcomes after stroke: A meta-analysis," PLOS ONE, Public Library of Science, vol. 18(4), pages 1-13, April.
    • Handle: RePEc:plo:pone00:0283204
    DOI: 10.1371/journal.pone.0283204
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