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A survival model for prognostic prediction based on ferroptosis-associated genes and the association with immune infiltration in lung squamous cell carcinoma

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  • Yanyi Lu
  • Hua Yang
  • Yunliang Cao
  • Yunan Wang
  • Mengjia Wu
  • Bo He
  • Junzhu Xu
  • Zixuan Su
  • Wen Luo
  • Yuyang Liu
  • Wei Hu

Abstract

Lung squamous cell carcinoma (LUSC) is the primary pathological type of lung cancer with a less favorable prognosis. This study attempts to construct a ferroptosis-associated signature associated with overall survival (OS) that can predict the prognosis of LUSC and explore its relationship with immune infiltration. A 5 ferroptosis-associated gene model was constructed by LASSO-penalized regression analysis to predict the prognosis of patients with LUSC in the TCGA database and validated in the GEO and TCGA databases. Patients were stratified into high-risk and low-risk groups by the median value of the risk scores, and the former prognosis was significantly worse (P

Suggested Citation

  • Yanyi Lu & Hua Yang & Yunliang Cao & Yunan Wang & Mengjia Wu & Bo He & Junzhu Xu & Zixuan Su & Wen Luo & Yuyang Liu & Wei Hu, 2023. "A survival model for prognostic prediction based on ferroptosis-associated genes and the association with immune infiltration in lung squamous cell carcinoma," PLOS ONE, Public Library of Science, vol. 18(3), pages 1-22, March.
    • Handle: RePEc:plo:pone00:0282888
    DOI: 10.1371/journal.pone.0282888
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