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Efficacy and safety of tranexamic acid in intracranial haemorrhage: A meta-analysis

Author

Listed:
  • Yu Xiong
  • Xiumei Guo
  • Xinyue Huang
  • Xiaodong Kang
  • Jianfeng Zhou
  • Chunhui Chen
  • Zhigang Pan
  • Linxing Wang
  • Roland Goldbrunner
  • Lampis Stavrinou
  • Pantelis Stavrinou
  • Shu Lin
  • Yuping Chen
  • Weipeng Hu
  • Feng Zheng

Abstract

Background: Although some studies have shown that tranexamic acid is beneficial to patients with intracranial haemorrhage, the efficacy and safety of tranexamic acid for intracranial haemorrhage remain controversial. Method: The PubMed, EMBASE, and Cochrane Library databases were systematically searched. The review followed PRISMA guidelines. Data were analyzed using the random-effects model. Results: Twenty-five randomized controlled trials were included. Tranexamic acid significantly inhibited hematoma growth in intracranial hemorrhage (ICH) and traumatic brain injury (TBI) patients. (ICH: mean difference -1.76, 95%CI -2.78 to -0.79, I2 = 0%, P

Suggested Citation

  • Yu Xiong & Xiumei Guo & Xinyue Huang & Xiaodong Kang & Jianfeng Zhou & Chunhui Chen & Zhigang Pan & Linxing Wang & Roland Goldbrunner & Lampis Stavrinou & Pantelis Stavrinou & Shu Lin & Yuping Chen & , 2023. "Efficacy and safety of tranexamic acid in intracranial haemorrhage: A meta-analysis," PLOS ONE, Public Library of Science, vol. 18(3), pages 1-13, March.
    • Handle: RePEc:plo:pone00:0282726
    DOI: 10.1371/journal.pone.0282726
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