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The efficacy and safety of 0.01% atropine alone or combined with orthokeratology for children with myopia: A meta-analysis

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  • Zengying Wang
  • Pengfei Wang
  • Bohua Jiang
  • Yifei Meng
  • Sufang Qie
  • Zhipeng Yan

Abstract

Objective: To evaluate the efficacy and safety of 0.01% atropine alone and in combination with orthokeratology for myopia control using a meta-analysis. Methods: PubMed, Cochrane Library, and EMBASE were searched. We included eligible randomized controlled trials (RCTs), non-RCTs, and retrospective cohort studies, published up to August 1, 2022. We calculated the weighted mean difference (WMD) and 95% confidence interval (CI) for all outcomes and plotted them in forest plots. Results: Fourteen studies were included; 4 and 11 in the 0.01% atropine monotherapy and atropine-orthokeratology (AOK) groups, respectively. Compared with orthokeratology (OK) alone, 0.01% atropine alone had similar effects on slowing the axial elongation (WMD: −0.00 mm; 95% CI: −0.05–0.04, p

Suggested Citation

  • Zengying Wang & Pengfei Wang & Bohua Jiang & Yifei Meng & Sufang Qie & Zhipeng Yan, 2023. "The efficacy and safety of 0.01% atropine alone or combined with orthokeratology for children with myopia: A meta-analysis," PLOS ONE, Public Library of Science, vol. 18(7), pages 1-17, July.
    • Handle: RePEc:plo:pone00:0282286
    DOI: 10.1371/journal.pone.0282286
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