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Efficacy of continuous positive airway pressure on TNF-α in obstructive sleep apnea patients: A meta-analysis

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  • Yong Luo
  • Fa-Rong Zhang
  • Jun-Lin Wu
  • Xi-Jiao Jiang

Abstract

Background: Tumor necrosis factor-α (TNF-α) is an important mediator of the immune response. At present, the improvement of TNF-α after continuous positive airway pressure (CPAP) treatment of obstructive sleep apnea-hypopnea syndrome (OSAHS) is still controversial. Methods: We conducted a systematic review of the present evidence based on a meta-analysis to elucidate the effects of TNF-α on OSAHS after CPAP treatment. Results: To measure TNF-α, ten studies used enzyme-linked immunosorbent assay (ELISA), and one used radioimmunoassay. The forest plot outcome indicated that CPAP therapy would lower the TNF-α levels in OSAHS patients, with a weighted mean difference (WMD) of 1.08 (95% CI: 0.62–1.55; P

Suggested Citation

  • Yong Luo & Fa-Rong Zhang & Jun-Lin Wu & Xi-Jiao Jiang, 2023. "Efficacy of continuous positive airway pressure on TNF-α in obstructive sleep apnea patients: A meta-analysis," PLOS ONE, Public Library of Science, vol. 18(3), pages 1-9, March.
    • Handle: RePEc:plo:pone00:0282172
    DOI: 10.1371/journal.pone.0282172
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