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Sex differences in long-term survival after intensive care unit treatment for sepsis: A cohort study

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  • Kelly Thompson
  • Naomi Hammond
  • Michael Bailey
  • Jai Darvall
  • Gary Low
  • Steven McGloughlin
  • Lucy Modra
  • David Pilcher

Abstract

Objective: To determine the effect of sex on sepsis-related ICU admission and survival for up to 3-years. Methods: Retrospective cohort study of adults admitted to Australian ICUs between 2018 and 2020. Men and women with a primary diagnosis of sepsis were included. The primary outcome of time to death for up to 3-years was examined using Kaplan Meier plots. Secondary outcomes included the duration of ICU and hospital stay. Results: Of 523,576 admissions, there were 63,039 (12·0%) sepsis-related ICU admissions. Of these, there were 50,956 patients (43·4% women) with 3-year survival data. Men were older (mean age 66·5 vs 63·6 years), more commonly received mechanical ventilation (27·4% vs 24·7%) and renal replacement therapy (8·2% vs 6·8%) and had worse survival (Hazard Ratio [HR] 1·11; 95% Confidence Interval [CI] 1·07 to 1·14, P

Suggested Citation

  • Kelly Thompson & Naomi Hammond & Michael Bailey & Jai Darvall & Gary Low & Steven McGloughlin & Lucy Modra & David Pilcher, 2023. "Sex differences in long-term survival after intensive care unit treatment for sepsis: A cohort study," PLOS ONE, Public Library of Science, vol. 18(2), pages 1-14, February.
    • Handle: RePEc:plo:pone00:0281939
    DOI: 10.1371/journal.pone.0281939
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