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Serum creatinine in predicting mortality after paraquat poisoning: A systematic review and meta-analysis

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  • Wei Huang
  • Zheng Zhang
  • Yuan-Qiang Lu

Abstract

Although the prognostic value of blood creatinine levels in patients with paraquat (PQ) poisoning has been studied for a long time, the results are still controversial. Therefore, we performed the first meta-analysis to comprehensively assess the value of blood creatinine in predicting the prognosis of patients with PQ poisoning. We searched PubMed, EMBase, Web of Science, ScienceDirect, Cochrane Library, China National Knowledge Infrastructure, China Science and Technology Journal Database, and China Online Journals to identify all relevant papers published up to June 2022. Data were extracted for pooled analysis, heterogeneity testing, sensitivity analysis, publication bias analysis, and subgroup analysis. Ultimately, 10 studies involving 862 patients were included. The I2 of diagnostic odds ratio (DOR), sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio of this study were all greater than 50%, which showed the existence of heterogeneity in this study, and a random effects model was used for the combination of the above five effect sizes. Pooled analysis showed a high predictive value of blood creatinine for prognosis of PQ poisoning [pooled DOR:22.92, 95% confidence interval (CI):15.62–33.65, P

Suggested Citation

  • Wei Huang & Zheng Zhang & Yuan-Qiang Lu, 2023. "Serum creatinine in predicting mortality after paraquat poisoning: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 18(2), pages 1-14, February.
    • Handle: RePEc:plo:pone00:0281897
    DOI: 10.1371/journal.pone.0281897
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