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Lobar emphysema ratio of more than 1% in the lobe with lung cancer as poor predictor for recurrence and overall survival in patients with stage I non-small cell lung cancer

Author

Listed:
  • Jeong Pyo Lee
  • Jae Bum Na
  • Ho Cheol Choi
  • Hye Young Choi
  • Ji Eun Kim
  • Hwa Seon Shin
  • Jung Ho Won
  • Sa Hong Jo
  • Seok Jin Hong
  • Won Jeong Yang
  • Yang Won Kim
  • Byeong Ju Koo
  • In Seok Jang
  • Mi Jung Park

Abstract

Background: The purpose of this study was to examine the relationship between the lobar emphysema ratio (LER) and tumor recurrence and survival in patients with stage I non-small cell lung cancer (NSCLC). Methods: We enrolled 258 patients with surgically proven stage I NSCLC. These patients underwent noncontrast chest CT, and pulmonary lobe segmentation and lobar emphysema quantification were performed using commercially available software. We assessed the LER in the lobe with lung cancer. We divided the patients into two groups according to the LER, and the cut-off value was 1. Furthermore, we analyzed the disease-free survival of high LER and other clinical factors after surgical resection. Results: The 258 patients were divided into two groups: low LER (n = 195) and high LER (n = 63). The right upper lobe was the most frequent location in lung cancer and the most severe location in emphysema. In the Kaplan‒Meier curve, high LER showed a significantly lower disease-free survival (8.21 ± 0.27 years vs 6.53 ± 0.60 years, p = 0.005) and overall survival (9.56 ± 0.15 years vs. 8.51 ± 0.49 years, p = 0.011) than low LER. Stage Ib (2.812 [1.661–4.762], p

Suggested Citation

  • Jeong Pyo Lee & Jae Bum Na & Ho Cheol Choi & Hye Young Choi & Ji Eun Kim & Hwa Seon Shin & Jung Ho Won & Sa Hong Jo & Seok Jin Hong & Won Jeong Yang & Yang Won Kim & Byeong Ju Koo & In Seok Jang & Mi , 2023. "Lobar emphysema ratio of more than 1% in the lobe with lung cancer as poor predictor for recurrence and overall survival in patients with stage I non-small cell lung cancer," PLOS ONE, Public Library of Science, vol. 18(2), pages 1-11, February.
    • Handle: RePEc:plo:pone00:0281715
    DOI: 10.1371/journal.pone.0281715
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