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Endothelial dysfunction in ME/CFS patients

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Listed:
  • Miriam Kristine Sandvik
  • Kari Sørland
  • Elisabeth Leirgul
  • Ingrid Gurvin Rekeland
  • Christina Særsten Stavland
  • Olav Mella
  • Øystein Fluge

Abstract

Objective: A few earlier studies have found impaired endothelial function in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The present study investigated large-vessel and small-vessel endothelial function in patients with ME/CFS. Study design: The study was a substudy of the RituxME trial, a national, multicenter, randomized, double-blind, placebo-controlled phase III study on the effect of rituximab vs. placebo in ME/CFS patients in Norway. Flow-mediated dilation (FMD) and post-occlusive reactive hyperemia (PORH) was measured at baseline and after 18 months of treatment in 39 patients and compared with healthy controls. Other outcome measures were symptom severity and various physical function measures. Results: ME/CFS patients had markedly reduced FMD compared to healthy controls at baseline (5.1% vs. 8.2%, p

Suggested Citation

  • Miriam Kristine Sandvik & Kari Sørland & Elisabeth Leirgul & Ingrid Gurvin Rekeland & Christina Særsten Stavland & Olav Mella & Øystein Fluge, 2023. "Endothelial dysfunction in ME/CFS patients," PLOS ONE, Public Library of Science, vol. 18(2), pages 1-15, February.
    • Handle: RePEc:plo:pone00:0280942
    DOI: 10.1371/journal.pone.0280942
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