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Community-based serum chloride abnormalities predict mortality risk

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  • Tali Shafat
  • Victor Novack
  • Leonid Barski
  • Yosef S Haviv

Abstract

Introduction: This population-based study aimed to investigate the prognostic value of ambulatory serum chloride abnormalities, often ignored by physicians. Methods: The study population included all non-hospitalized adult patients, insured by "Clalit" Health Services in Israel’s southern district, who underwent at least 3 serum chloride tests in community-based clinics during 2005–2016. For each patient, each period with low (≤97 mmol/l), high (≥107 mmol/l) or normal chloride levels were recorded. A Cox proportional hazards model was used to estimate the mortality risk of hypochloremia and hyperchloremia periods. Results: 664,253 serum chloride tests from 105,655 subjects were analyzed. During a median follow up of 10.8 years, 11,694 patients died. Hypochloremia (≤ 97 mmol/l) was independently associated with elevated all-cause mortality risk after adjusting for age, co-morbidities, hyponatremia and eGFR (HR 2.41, 95%CI 2.16–2.69, p

Suggested Citation

  • Tali Shafat & Victor Novack & Leonid Barski & Yosef S Haviv, 2023. "Community-based serum chloride abnormalities predict mortality risk," PLOS ONE, Public Library of Science, vol. 18(2), pages 1-13, February.
    • Handle: RePEc:plo:pone00:0279837
    DOI: 10.1371/journal.pone.0279837
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