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A network meta-analysis of 12,116 individuals from randomized controlled trials in the treatment of depression after acute coronary syndrome

Author

Listed:
  • Grace En Hui Lim
  • Ansel Tang
  • Yip Han Chin
  • Jie Ning Yong
  • Darren Tan
  • Phoebe Tay
  • Yu Yi Chan
  • Denzel Ming Wei Lim
  • Jun Wei Yeo
  • Kai En Chan
  • Kamala Devi
  • Colin Eng Choon Ong
  • Roger S Y Foo
  • Huay-Cheem Tan
  • Mark Y Chan
  • Roger Ho
  • Poay Huan Loh
  • Nicholas W S Chew

Abstract

Background: Post-acute coronary syndrome (ACS) depression is a common but not well understood complication experienced by ACS patients. Research on the effectiveness of various therapies remains limited. Hence, we sought to conduct a network meta-analysis to assess the efficacy of different interventions for post-ACS depression in improving patient outcomes. Methods and findings: Three electronic databases were searched for randomised controlled trials describing different depression treatment modalities in post-ACS patients. Each article was screened based on inclusion criteria and relevant data were extracted. A bivariate analysis and a network meta-analysis was performed using risk ratios (RR) and standardized mean differences (SMD) for binary and continuous outcomes, respectively. Conclusion: This network meta-analysis found that the treatment effect of the various psychological modalities on depression severity were similar. Future trials on psychological interventions assessing clinical outcomes and improvement in adherence to ACS-specific interventions are needed.

Suggested Citation

  • Grace En Hui Lim & Ansel Tang & Yip Han Chin & Jie Ning Yong & Darren Tan & Phoebe Tay & Yu Yi Chan & Denzel Ming Wei Lim & Jun Wei Yeo & Kai En Chan & Kamala Devi & Colin Eng Choon Ong & Roger S Y Fo, 2022. "A network meta-analysis of 12,116 individuals from randomized controlled trials in the treatment of depression after acute coronary syndrome," PLOS ONE, Public Library of Science, vol. 17(11), pages 1-17, November.
    • Handle: RePEc:plo:pone00:0278326
    DOI: 10.1371/journal.pone.0278326
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