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Effect of physical activity on the risk of frailty: A systematic review and meta-analysis

Author

Listed:
  • Wenjing Zhao
  • Peng Hu
  • Weidi Sun
  • Weidong Wu
  • Jinhua Zhang
  • Hai Deng
  • Jun Huang
  • Shigekazu Ukawa
  • Jiahai Lu
  • Akiko Tamakoshi
  • Xudong Liu

Abstract

Objective: The relationship between physical activity (PA) and the risk of frailty has not reached a conclusive result. This systematic review with meta-analysis aimed to evaluate the effect of PA on the onset of frailty in the community-dwelling middle and older age adults by pooling data from cohort studies. Methods: A systematic literature search was performed via PubMed, Embase, and Web of Science up to June 01, 2021. Pooled adjusted effect estimates (ES) with 95% confidence interval (CI) were calculated by using the random-effect model and by comparing the highest with lowest levels of PA. Heterogeneity was tested using the I2 statistic and Q-test. The quality of evidence was evaluated by using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Results: A total of ten cohort studies with 14 records were selected, and the GRADE approach classified the quality of evidence as low. In comparison with the lowest level of PA, the highest level of PA was associated with 41% decreased odds of frailty (ES: 0.59, 95% CI: 0.51–0.67; I2 = 70.0%, P-heterogeneity

Suggested Citation

  • Wenjing Zhao & Peng Hu & Weidi Sun & Weidong Wu & Jinhua Zhang & Hai Deng & Jun Huang & Shigekazu Ukawa & Jiahai Lu & Akiko Tamakoshi & Xudong Liu, 2022. "Effect of physical activity on the risk of frailty: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 17(12), pages 1-16, December.
    • Handle: RePEc:plo:pone00:0278226
    DOI: 10.1371/journal.pone.0278226
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    References listed on IDEAS

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    1. Andres Gil-Salcedo & Aline Dugravot & Aurore Fayosse & Julien Dumurgier & Kim Bouillon & Alexis Schnitzler & Mika Kivimäki & Archana Singh-Manoux & Séverine Sabia, 2020. "Healthy behaviors at age 50 years and frailty at older ages in a 20-year follow-up of the UK Whitehall II cohort: A longitudinal study," PLOS Medicine, Public Library of Science, vol. 17(7), pages 1-19, July.
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