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Obesity in children and adolescents and the risk of ovarian cancer: A systematic review and dose‒response meta-analysis

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  • Nan Ding
  • Junyi Zhan
  • Youjin Shi
  • Tianci Qiao
  • Panpan Li
  • Tingting Zhang

Abstract

Objective: The relationship between obesity in children and adolescents and the risk of ovarian cancer remains controversial. The aim of this meta-analysis was to explore the exact shape of this relationship. Methods: We conducted dose‒response meta-analyses of cohort and case‒control studies, including published studies derived from searches in the PubMed, Embase, Web of Science and Cochrane Library databases until October 2022. Pooled effect size estimates are expressed as relative risks (RRs) or odds ratios (ORs) with 95% confidence intervals (CIs) and were evaluated by fixed-effect models. A nonlinear dose‒response meta-analysis was performed by using a restricted cubic spline model. Results: After screening 4215 publications, 10 studies were included in the present meta-analysis. Overall analyses revealed statistically significant associations of obesity in children and adolescents with ovarian cancer (adjusted RR = 1.19, 95% CI: 1.11 to 1.28, P

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  • Nan Ding & Junyi Zhan & Youjin Shi & Tianci Qiao & Panpan Li & Tingting Zhang, 2022. "Obesity in children and adolescents and the risk of ovarian cancer: A systematic review and dose‒response meta-analysis," PLOS ONE, Public Library of Science, vol. 17(12), pages 1-14, December.
    • Handle: RePEc:plo:pone00:0278050
    DOI: 10.1371/journal.pone.0278050
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    1. David Holmes, 2015. "Ovarian cancer: beyond resistance," Nature, Nature, vol. 527(7579), pages 217-217, November.
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    1. Hitomi Ogata & Yosuke Isoyama & Sayaka Nose-Ogura & Narumi Nagai & Momoko Kayaba & João Gabriel Segato Kruse & Ivan Seleznov & Miki Kaneko & Taiki Shigematsu & Ken Kiyono, 2024. "Allometric multi-scaling of weight-for-height relation in children and adolescents: Revisiting the theoretical basis of body mass index of thinness and obesity assessment," PLOS ONE, Public Library of Science, vol. 19(7), pages 1-25, July.

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