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Estimating the economic burden of typhoid in children and adults in Blantyre, Malawi: A costing cohort study

Author

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  • Fumbani Limani
  • Christopher Smith
  • Richard Wachepa
  • Hlulose Chafuwa
  • James Meiring
  • Patrick Noah
  • Pratiksha Patel
  • Priyanka D Patel
  • Frédéric Debellut
  • Clint Pecenka
  • Melita A Gordon
  • Naor Bar-Zeev

Abstract

Background: Typhoid causes preventable death and disease. The World Health Organization recommends Typhoid Conjugate Vaccine for endemic countries, but introduction decisions depend on cost-effectiveness. We estimated household and healthcare economic burdens of typhoid in Blantyre, Malawi. Methods: In a prospective cohort of culture-confirmed typhoid cases at two primary- and a referral-level health facility, we collected direct medical, non-medical costs (2020 U.S. dollars) to healthcare provider, plus indirect costs to households. Results: From July 2019-March 2020, of 109 cases, 63 (58%) were 40% of non-food monthly household expenditure, occurred in 48 (44%) households. Conclusions: Typhoid can be economically catastrophic for families, despite accessible free medical care. Typhoid is costly for government healthcare provision. These data make an economic case for TCV introduction in Malawi and the region and will be used to derive vaccine cost-effectiveness.

Suggested Citation

  • Fumbani Limani & Christopher Smith & Richard Wachepa & Hlulose Chafuwa & James Meiring & Patrick Noah & Pratiksha Patel & Priyanka D Patel & Frédéric Debellut & Clint Pecenka & Melita A Gordon & Naor , 2022. "Estimating the economic burden of typhoid in children and adults in Blantyre, Malawi: A costing cohort study," PLOS ONE, Public Library of Science, vol. 17(11), pages 1-10, November.
    • Handle: RePEc:plo:pone00:0277419
    DOI: 10.1371/journal.pone.0277419
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    References listed on IDEAS

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    1. Marina Antillón & Joshua L Warren & Forrest W Crawford & Daniel M Weinberger & Esra Kürüm & Gi Deok Pak & Florian Marks & Virginia E Pitzer, 2017. "The burden of typhoid fever in low- and middle-income countries: A meta-regression approach," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 11(2), pages 1-21, February.
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