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D-dimer levels in non-COVID-19 ARDS and COVID-19 ARDS patients: A systematic review with meta-analysis

Author

Listed:
  • Krisztina Tóth
  • Stefano Fresilli
  • Nicola Paoli
  • Giacomo Maiucci
  • Mariateresa Salvioni
  • Yuki Kotani
  • Stephan Katzenschlager
  • Markus A Weigand
  • Giovanni Landoni

Abstract

Background: Hypercoagulability and thrombo-inflammation are the main reasons for death in COVID-19 patients. It is unclear whether there is a difference between D-dimer levels in patients without or with COVID-19 acute respiratory distress syndrome (ARDS). Methods: We searched PubMed, EMBASE, and ClinicalTrails.gov databases looking for studies reporting D-dimer levels in patients without or with COVID-19 ARDS. Secondary endpoints included length of hospital stay, and mortality data at the longest follow-up available. Results: We included 12 retrospective and 3 prospective studies with overall 2,828 patients, of whom 1,404 (49.6%) had non-COVID-19 ARDS and 1,424 had COVID-19 ARDS. D-dimer levels were not significantly higher in non-COVID-19 ARDS than in COVID-19 ARDS patients (mean 7.65 mg/L vs. mean 6.20 mg/L MD 0.88 [CI: -0.61 to 2.38] p = 0.25; I² = 85%) while the length of hospital stay was shorter (non-COVID-19 mean 37.4 days vs. COVID-19 mean 48.5 days, MD -10.92 [CI: -16.71 to -5.14] p

Suggested Citation

  • Krisztina Tóth & Stefano Fresilli & Nicola Paoli & Giacomo Maiucci & Mariateresa Salvioni & Yuki Kotani & Stephan Katzenschlager & Markus A Weigand & Giovanni Landoni, 2023. "D-dimer levels in non-COVID-19 ARDS and COVID-19 ARDS patients: A systematic review with meta-analysis," PLOS ONE, Public Library of Science, vol. 18(2), pages 1-10, February.
    • Handle: RePEc:plo:pone00:0277000
    DOI: 10.1371/journal.pone.0277000
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    1. Stephan Katzenschlager & Alexandra J Zimmer & Claudius Gottschalk & Jürgen Grafeneder & Stephani Schmitz & Sara Kraker & Marlene Ganslmeier & Amelie Muth & Alexander Seitel & Lena Maier-Hein & Andrea , 2021. "Can we predict the severe course of COVID-19 - a systematic review and meta-analysis of indicators of clinical outcome?," PLOS ONE, Public Library of Science, vol. 16(7), pages 1-19, July.
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