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Association between circulating SerpinB1 levels and insulin sensitivity in Japanese with type 2 diabetes: A single-center, cross-sectional, observational study

Author

Listed:
  • Mayu Kyohara
  • Daisuke Miyashita
  • Ryota Inoue
  • Kuniyuki Nishiyama
  • Takahiro Tsuno
  • Tomoko Okuyama
  • Yu Togashi
  • Yasuo Terauchi
  • Jun Shirakawa

Abstract

Plasma and liver SerpinB1 levels are elevated in mice with insulin resistance and promote β-cell proliferation in human islets. We measured serum SerpinB1 levels in Japanese subjects with or without type 2 diabetes (T2DM). We enrolled 12 normal glucose tolerance (NGT) and 51 T2DM subjects. There was no difference in serum SerpinB1 levels between the 2 groups (T2DM, 1.3 ± 0.9 ng/mL vs. NGT, 1.8 ± 1.7 ng/mL; P = 0.146). After adjusting for age and sex, the serum SerpinB1 levels were positively correlated with HOMA2-%S (β = 0.319, P = 0.036), and negatively correlated with fasting blood glucose (β = -0.365, P = 0.010), total cholesterol (β = -0.396, P = 0.006), low-density lipoprotein (LDL) cholesterol (β = -0.411, P = 0.004), triglycerides (β = -0.321, P = 0.026), and γGTP (β = -0.322, P = 0.026) in subjects with T2DM. Thus, circulating SerpinB1 is possibly associated with insulin sensitivity and better blood glucose level in Japanese subjects with T2DM.Trial registration: UMIN Clinical Trials Registry, UMIN000020453.

Suggested Citation

  • Mayu Kyohara & Daisuke Miyashita & Ryota Inoue & Kuniyuki Nishiyama & Takahiro Tsuno & Tomoko Okuyama & Yu Togashi & Yasuo Terauchi & Jun Shirakawa, 2022. "Association between circulating SerpinB1 levels and insulin sensitivity in Japanese with type 2 diabetes: A single-center, cross-sectional, observational study," PLOS ONE, Public Library of Science, vol. 17(11), pages 1-9, November.
    • Handle: RePEc:plo:pone00:0276915
    DOI: 10.1371/journal.pone.0276915
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