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Opioid and gabapentinoid prescriptions in England from 2015 to 2020

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  • Yixue Xia
  • Patrice Forget

Abstract

Purpose: Concerns gradually arose about misuse of gabapentinoids (gabapentin and pregabalin), especially when used in combination with opioids. Because it can be a driver of usage, trends in prescribing habits may be interesting to analyse. The aim of this study is to examine the evolution of prescriptions of opioids and gabapentinoids in England from 2015 to 2020 at a regional level. Methods: This study included data from April 2015 to February 2020, focusing on prescribing data, extracted the OpenPrescribing database. We described the evolution of the prescriptions of opioids and gabapentinoids and calculated their ratios for each month. We used Analyses of Variance (ANOVAs) to compare data between and within regions (over time). Results: During this period, opioid prescriptions remained stable (from -3.3% to +2.2%/year) and increased for gabapentinoids generally (from +1.5% to +2.2%). The ratio between gabapentinoid to opioid prescriptions increased by more than 20% in 2020 compared to 2015, variably between regions (F(6,406) = [120.2]; P

Suggested Citation

  • Yixue Xia & Patrice Forget, 2022. "Opioid and gabapentinoid prescriptions in England from 2015 to 2020," PLOS ONE, Public Library of Science, vol. 17(11), pages 1-10, November.
    • Handle: RePEc:plo:pone00:0276867
    DOI: 10.1371/journal.pone.0276867
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