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Posthemorrhagic ventricular dilatation late intervention threshold and associated brain injury

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  • Eva Valverde
  • Marta Ybarra
  • Andrea V Benito
  • María Carmen Bravo
  • Adelina Pellicer

Abstract

Objective: To systematically assess white matter injury (WMI) in preterm infants with posthemorrhagic ventricular dilatation (PHVD) using a high-threshold intervention strategy. Study design: This retrospective analysis included 85 preterm infants (≤34 weeks of gestation) with grade 2–3 germinal matrix-intraventricular hemorrhage. Cranial ultrasound (cUS) scans were assessed for WMI and ventricular width and shape. Forty-eight infants developed PHVD, 21 of whom (intervention group) underwent cerebrospinal fluid drainage according to a predefined threshold (ventricular index ≥p97+4 mm or anterior horn width >10 mm, and the presence of frontal horn ballooning). The other 27 infants underwent a conservative approach (non-intervention group). The two PHVD groups were compared regarding ventricular width at two stages: the worst cUS for the non-intervention group (scans showing the largest ventricular measurements) versus pre-intervention cUS in the intervention group, and at term equivalent age. WMI was classified as normal/mild, moderate and severe. Results: The intervention group showed significantly larger ventricular index, anterior horn width and thalamo-occipital diameter than the non-intervention group at the two timepoints. Moderate and severe WMI were more frequent in the infants with PHVD (p

Suggested Citation

  • Eva Valverde & Marta Ybarra & Andrea V Benito & María Carmen Bravo & Adelina Pellicer, 2022. "Posthemorrhagic ventricular dilatation late intervention threshold and associated brain injury," PLOS ONE, Public Library of Science, vol. 17(10), pages 1-11, October.
    • Handle: RePEc:plo:pone00:0276446
    DOI: 10.1371/journal.pone.0276446
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