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Association between XRCC3 p.Thr241Met polymorphism and risk of glioma: A systematic review and meta-analysis

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  • Shing Cheng Tan
  • Teck Yew Low
  • Hafiz Muhammad Jafar Hussain
  • Mohamad Ayub Khan Sharzehan
  • Hilary Sito
  • Hamed Kord-Varkaneh
  • Md Asiful Islam

Abstract

Background: The XRCC3 p.Thr241Met (rs861539) polymorphism has been extensively studied for its association with glioma risk, but results remain conflicting. Therefore, we performed a systematic review and meta-analysis to resolve this inconsistency. Methods: Studies published up to June 10, 2022, were searched in PubMed, Web of Science, Scopus, VIP, Wanfang, and China National Knowledge Infrastructure databases and screened for eligibility. Then, the combined odds ratio (OR) of the included studies was estimated based on five genetic models, i.e., homozygous (Met/Met vs. Thr/Thr), heterozygous (Thr/Met vs. Thr/Thr), dominant (Thr/Met + Met/Met vs. Thr/Thr), recessive (Met/Met vs. Thr/Thr + Thr/Met) and allele (Met vs. Thr). The study protocol was preregistered at PROSPERO (registration number: CRD42021235704). Results: Overall, our meta-analysis of 14 eligible studies involving 12,905 subjects showed that the p.Thr241Met polymorphism was significantly associated with increased glioma risk in both homozygous and recessive models (homozygous, OR = 1.381, 95% CI = 1.081–1.764, P = 0.010; recessive, OR = 1.305, 95% CI = 1.140–1.493, P 0.05). Conclusion: We demonstrated that the XRCC3 p.Thr241Met polymorphism is associated with an increased risk of glioma only in the homozygous and recessive models.

Suggested Citation

  • Shing Cheng Tan & Teck Yew Low & Hafiz Muhammad Jafar Hussain & Mohamad Ayub Khan Sharzehan & Hilary Sito & Hamed Kord-Varkaneh & Md Asiful Islam, 2022. "Association between XRCC3 p.Thr241Met polymorphism and risk of glioma: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 17(10), pages 1-15, October.
    • Handle: RePEc:plo:pone00:0276313
    DOI: 10.1371/journal.pone.0276313
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    1. Matteo Berti & Federico Teloni & Sofija Mijic & Sebastian Ursich & Jevgenij Fuchs & Maria Dilia Palumbieri & Jana Krietsch & Jonas A. Schmid & Edwige B. Garcin & Stéphanie Gon & Mauro Modesti & Matthi, 2020. "Sequential role of RAD51 paralog complexes in replication fork remodeling and restart," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
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