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Invariant structural and functional brain regions associated with tinnitus: A meta-analysis

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  • John C Moring
  • Fatima T Husain
  • Jodie Gray
  • Crystal Franklin
  • Alan L Peterson
  • Patricia A Resick
  • Amy Garrett
  • Carlos Esquivel
  • Peter T Fox

Abstract

Tinnitus is a common, functionally disabling condition of often unknown etiology. Neuroimaging research to better understand tinnitus is emerging but remains limited in scope. Voxel-based physiology (VBP) studies detect tinnitus-associated pathophysiology by group-wise contrast (tinnitus vs controls) of resting-state indices of hemodynamics, metabolism, and neurovascular coupling. Voxel-based morphometry (VBM) detects tinnitus-associated neurodegeneration by group-wise contrast of structural MRI. Both VBP and VBM studies routinely report results as atlas-referenced coordinates, suitable for coordinate-based meta-analysis (CBMA). Here, 17 resting-state VBP and 8 VBM reports of tinnitus-associated regional alterations were meta-analyzed using activation likelihood estimation (ALE). Acknowledging the need for data-driven insights, ALEs were performed at two levels of statistical rigor: corrected for multiple comparisons and uncorrected. The corrected ALE applied cluster-level inference thresholding by intensity (z-score > 1.96; p

Suggested Citation

  • John C Moring & Fatima T Husain & Jodie Gray & Crystal Franklin & Alan L Peterson & Patricia A Resick & Amy Garrett & Carlos Esquivel & Peter T Fox, 2022. "Invariant structural and functional brain regions associated with tinnitus: A meta-analysis," PLOS ONE, Public Library of Science, vol. 17(10), pages 1-17, October.
    • Handle: RePEc:plo:pone00:0276140
    DOI: 10.1371/journal.pone.0276140
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    1. Freya Acar & Ruth Seurinck & Simon B Eickhoff & Beatrijs Moerkerke, 2018. "Assessing robustness against potential publication bias in Activation Likelihood Estimation (ALE) meta-analyses for fMRI," PLOS ONE, Public Library of Science, vol. 13(11), pages 1-23, November.
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