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Homocysteine is associated with higher risks of ischemic stroke: A systematic review and meta-analysis

Author

Listed:
  • Nícollas Nunes Rabelo
  • João Paulo Mota Telles
  • Leonardo Zumerkorn Pipek
  • Rafaela Farias Vidigal Nascimento
  • Rodrigo Coimbra de Gusmão
  • Manoel Jacobsen Teixeira
  • Eberval Gadelha Figueiredo

Abstract

Background: High levels of homocysteine (Hct) have been associated with great risks of ischemic stroke. However, some controversy still exists. We performed a systematic review and meta-analysis to compare the levels of Hct between patients with ischemic stroke and controls. Methods: We performed a systematic literature search for articles reporting Hct levels of patients with occurrence of ischemic stroke. We employed a random-effects inverse-variance weighted meta-analytical approach in order to pool standardized mean differences, with estimation of τ2 through the DerSimonian-Laird method. Results: The initial search yielded 1361 studies. After careful analysis of abstracts and full texts, the meta-analysis included data from 38 studies, which involved almost 16 000 stroke events. However, only 13 studies reported means and standard deviations for cases and controls, and therefore were used in the meta-analysis. Those studies presented data from 5002 patients with stroke and 4945 controls. Standardized mean difference was 1.67 (95% CI 1.00–2.25, P

Suggested Citation

  • Nícollas Nunes Rabelo & João Paulo Mota Telles & Leonardo Zumerkorn Pipek & Rafaela Farias Vidigal Nascimento & Rodrigo Coimbra de Gusmão & Manoel Jacobsen Teixeira & Eberval Gadelha Figueiredo, 2022. "Homocysteine is associated with higher risks of ischemic stroke: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 17(10), pages 1-20, October.
    • Handle: RePEc:plo:pone00:0276087
    DOI: 10.1371/journal.pone.0276087
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