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Investigation of urinary metabolomics in a phase I hookworm vaccine trial in Gabon

Author

Listed:
  • Madeleine Eunice Betouke Ongwe
  • Yoanne D Mouwenda
  • Koen A Stam
  • Peter G Kremsner
  • Bertrand Lell
  • David Diemert
  • Jeff Bethony
  • Maria E Bottazzi
  • Peter J Hotez
  • Remko V Leeuwen
  • Martin P Grobusch
  • Ayola A Adegnika
  • Oleg A Mayboroda
  • Maria Yazdanbakhsh

Abstract

Metabolomics provides a powerful tool to study physiological changes in response to various perturbations such as vaccination. We explored whether metabolomic changes could be seen after vaccination in a phase I trial where Gabonese adults living either in rural or semi-urban areas received the subunit hookworm vaccine candidates (Na-GST-1 and Na-APR-1 (M74) adjuvanted with Alhydrogel plus GLA-AF (n = 24) or the hepatitis B vaccine (n = 8) as control. Urine samples were collected and assayed using targeted 1H NMR spectroscopy. At baseline, a set of metabolites significantly distinguished rural from semi-urban individuals. The pre- and post-vaccination comparisons indicated significant changes in few metabolites but only one day after the first vaccination. There was no relationship with immunogenicity. In conclusion, in a small phase 1 trial, urinary metabolomics could distinguish volunteers with different environmental exposures and reflected the safety of the vaccines but did not show a relationship to immunogenicity.

Suggested Citation

  • Madeleine Eunice Betouke Ongwe & Yoanne D Mouwenda & Koen A Stam & Peter G Kremsner & Bertrand Lell & David Diemert & Jeff Bethony & Maria E Bottazzi & Peter J Hotez & Remko V Leeuwen & Martin P Grobu, 2022. "Investigation of urinary metabolomics in a phase I hookworm vaccine trial in Gabon," PLOS ONE, Public Library of Science, vol. 17(9), pages 1-11, September.
    • Handle: RePEc:plo:pone00:0275013
    DOI: 10.1371/journal.pone.0275013
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