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Tumor growth monitoring in breast cancer xenografts: A good technique for a strong ethic

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  • Anne Rodallec
  • Cristina Vaghi
  • Joseph Ciccolini
  • Raphaelle Fanciullino
  • Sebastien Benzekry

Abstract

Purpose: Although recent regulations improved conditions of laboratory animals, their use remains essential in cancer research to determine treatment efficacy. In most cases, such experiments are performed on xenografted animals for which tumor volume is mostly estimated from caliper measurements. However, many formulas have been employed for this estimation and no standardization is available yet. Methods: Using previous animal studies, we compared all formulas used by the scientific community in 2019. Data were collected from 93 mice orthotopically xenografted with human breast cancer cells. All formulas were evaluated and ranked based on correlation and lower mean relative error. They were then used in a Gompertz quantitative model of tumor growth. Results: Seven formulas for tumor volume estimation were identified and a statistically significant difference was observed among them (ANOVA test, p

Suggested Citation

  • Anne Rodallec & Cristina Vaghi & Joseph Ciccolini & Raphaelle Fanciullino & Sebastien Benzekry, 2022. "Tumor growth monitoring in breast cancer xenografts: A good technique for a strong ethic," PLOS ONE, Public Library of Science, vol. 17(9), pages 1-13, September.
    • Handle: RePEc:plo:pone00:0274886
    DOI: 10.1371/journal.pone.0274886
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