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Neurofilament light chain in blood as a diagnostic and predictive biomarker for multiple sclerosis: A systematic review and meta-analysis

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  • Liangxia Ning
  • Bin Wang

Abstract

Background: Neurofilament light chain (NfL) in cerebrospinal fluid (CSF) is a biomarker of multiple sclerosis (MS). However, CSF sampling is invasive and has limited the clinical application. With the development of highly sensitive single-molecule assay, the accurate quantification of the very low NfL levels in blood become feasible. As evidence being accumulated, we performed a meta-analysis to evaluate the diagnostic and predictive value of blood NfL in MS patients. Methods: We performed literature search on PubMed, EMBASE, Web of Science and Cochrane Library from inception to May 31, 2022. The blood NfL differences between MS vs. controls, MS vs. clinically isolated syndrome (CIS), progressive MS (PMS) vs. relapsing-remitting MS (RRMS), and MS in relapse vs. MS in remission were estimated by standard mean difference (SMD) and corresponding 95% confidence interval (CI). Pooled hazard ratio (HR) and 95%CI were calculated to predict time to reach Expanded Disability Status Scale (EDSS) score≥4.0 and to relapse. Results: A total of 28 studies comprising 6545 MS patients and 2477 controls were eligible for meta-analysis of diagnosis value, and 5 studies with 4444 patients were synthesized in analysis of predictive value. Blood NfL levels were significantly higher in MS patients vs. age-matched controls (SMD = 0.64, 95%CI 0.44–0.85, P

Suggested Citation

  • Liangxia Ning & Bin Wang, 2022. "Neurofilament light chain in blood as a diagnostic and predictive biomarker for multiple sclerosis: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 17(9), pages 1-18, September.
    • Handle: RePEc:plo:pone00:0274565
    DOI: 10.1371/journal.pone.0274565
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    1. Michael Khalil & Lukas Pirpamer & Edith Hofer & Margarete M. Voortman & Christian Barro & David Leppert & Pascal Benkert & Stefan Ropele & Christian Enzinger & Franz Fazekas & Reinhold Schmidt & Jens , 2020. "Serum neurofilament light levels in normal aging and their association with morphologic brain changes," Nature Communications, Nature, vol. 11(1), pages 1-9, December.
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