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Sex differences in saliva-based DNA methylation changes and environmental stressor in young African American adults

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  • Forough Saadatmand
  • Muneer Abbas
  • Victor Apprey
  • Krishma Tailor
  • Bernard Kwabi-Addo

Abstract

Background: Low socioeconomic status neighborhood exposure to stress and violence may be sources of negative stimuli that poses significant health risks for children, adolescents and throughout the life course of an individual. The study aims to investigate if aberrant epigenetic DNA methylation changes may be a potential mechanism for regulating neighborhood exposures and health outcomes. Methods: Exposure to environmental stressors identified in 98 young African American (AA) adults aged 18–25 years old from the Washington D.C., area were used in the study. We correlated the association between stress markers; cortisol, CRP, IgG, IGA, IgM, and self-reported exposure to violence and stress, with quantitative DNA methylation changes in a panel of gene-specific loci using saliva DNA. Results: In all participants studied, the exposure to violence was significant and negatively correlated with DNA methylation of MST1R loci (p = 0.032; r = -0.971) and nominally significant with NR3C1 loci (p = 0.053; r = -0.948). In addition, we observed significant and negative correlation of DNA methylation changes of LINE1 (p = 0.044; r = -0.248); NR3C1 (p = 0.017; r = -0.186); MSTR1 (p = 0.022; r = -0.192); and DRD2 (p = 0.056; r = -0.184; albeit nominal significant correlation) with IgA expression. On the other hand, we observed a significant and position correlation of DNA methylation changes in DRD2 (p = 0.037; r = 0.184) with IgG expression. When participants were stratified by sex, we observed in AA young male adults, significant DNA methylation changes of MST1R (p

Suggested Citation

  • Forough Saadatmand & Muneer Abbas & Victor Apprey & Krishma Tailor & Bernard Kwabi-Addo, 2022. "Sex differences in saliva-based DNA methylation changes and environmental stressor in young African American adults," PLOS ONE, Public Library of Science, vol. 17(9), pages 1-15, September.
    • Handle: RePEc:plo:pone00:0273717
    DOI: 10.1371/journal.pone.0273717
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