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Clinical trial and detection of SARS-CoV-2 by a commercial breath analysis test based on Terahertz technology

Author

Listed:
  • Meila Bastos De Almeida
  • Regina Aharonov-Nadborny
  • Eran Gabbai
  • Ana Paula Palka
  • Leticia Schiavo
  • Elis Esmanhoto
  • Irina Riediger
  • Jaime Rocha
  • Ariel Margulis
  • Marcelo Loureiro
  • Christina Pettan-Brewer
  • Louise Bach Kmetiuk
  • Ivan Roque De Barros-Filho
  • Alexander Welker Biondo

Abstract

Public health threats such as the current COVID-19 pandemics have required prompt action by the local, national, and international authorities. Rapid and noninvasive diagnostic methods may provide on-site detection and immediate social isolation, used as tools to rapidly control virus spreading. Accordingly, the aim of the present study was to evaluate a commercial breath analysis test (TERA.Bio®) and deterministic algorithm for detecting the SARS-CoV-2 spectral signature of Volatile Organic Compounds present in exhaled air samples of suspicious persons from southern Brazil. A casuistic total of 70 infected and 500 non-infected patients were sampled, tested, and results later compared to RT-qPCR as gold standard. Overall, the test showed 92.6% sensitivity and 96.0% specificity. No statistical correlation was observed between SARS-CoV-2 positivity and infection by other respiratory diseases. Further studies should focus on infection monitoring among asymptomatic persons. In conclusion, the breath analysis test herein may be used as a fast, on-site, and easy-to-apply screening method for diagnosing COVID-19.

Suggested Citation

  • Meila Bastos De Almeida & Regina Aharonov-Nadborny & Eran Gabbai & Ana Paula Palka & Leticia Schiavo & Elis Esmanhoto & Irina Riediger & Jaime Rocha & Ariel Margulis & Marcelo Loureiro & Christina Pet, 2022. "Clinical trial and detection of SARS-CoV-2 by a commercial breath analysis test based on Terahertz technology," PLOS ONE, Public Library of Science, vol. 17(9), pages 1-14, September.
    • Handle: RePEc:plo:pone00:0273506
    DOI: 10.1371/journal.pone.0273506
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