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Clinical and biological prognostic factors in follicular lymphoma patients

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  • Ádám Jóna
  • Anna Kenyeres
  • Sándor Barna
  • Árpád Illés
  • Zsófia Simon

Abstract

Introduction: Follicular lymphoma (FL) is an indolent, yet heterogeneous, B-cell lymphoproliferative disorder. Although most FL patients respond well to treatment, few with specific traits have a poor prognosis; the latter are difficult to define. Patients and methods: We retrospectively analyzed data from 143 FL patients treated at the University of Debrecen since 2009 and investigated prognostic factors that may influence the survival of FL patients. Results: A maximum standardized uptake value (SUVmax) cut-off of 9.85 at the staging positron emission tomography/computed tomography (PET/CT) (p = 0.0001, hazard ratio [HR]: 0.2535, 95% confidence interval [CI]: 0.1118–0.4878) and a lymphocyte/monocyte (Ly/Mo) ratio of 3.41 (p = 0.0027, HR: 2.997, 95% CI: 1.463–6.142), drawn at diagnosis, significantly predicted FL patients’ progression-free survival (PFS). A staging SUVmax >9.85 with Ly/Mo 9.85 in conjunction with interim SUVmax >3.15 predicted poor prognosis (p

Suggested Citation

  • Ádám Jóna & Anna Kenyeres & Sándor Barna & Árpád Illés & Zsófia Simon, 2022. "Clinical and biological prognostic factors in follicular lymphoma patients," PLOS ONE, Public Library of Science, vol. 17(8), pages 1-14, August.
    • Handle: RePEc:plo:pone00:0272787
    DOI: 10.1371/journal.pone.0272787
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