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Shared genetic architecture of hernias: A genome-wide association study with multivariable meta-analysis of multiple hernia phenotypes

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Listed:
  • Waheed Ul-Rahman Ahmed
  • Manal I A Patel
  • Michael Ng
  • James McVeigh
  • Krina Zondervan
  • Akira Wiberg
  • Dominic Furniss

Abstract

Abdominal hernias are common and characterised by the abnormal protrusion of a viscus through the wall of the abdominal cavity. The global incidence is 18.5 million annually and there are limited non-surgical treatments. To improve understanding of common hernia aetiopathology, we performed a six-stage genome-wide association study (GWAS) of 62,637 UK Biobank participants with either single or multiple hernia phenotypes including inguinal, femoral, umbilical and hiatus hernia. Additionally, we performed multivariable meta-analysis with metaUSAT, to allow integration of summary data across traits to generate combined effect estimates. On individual hernia analysis, we identified 3404 variants across 38 genome-wide significant (p

Suggested Citation

  • Waheed Ul-Rahman Ahmed & Manal I A Patel & Michael Ng & James McVeigh & Krina Zondervan & Akira Wiberg & Dominic Furniss, 2022. "Shared genetic architecture of hernias: A genome-wide association study with multivariable meta-analysis of multiple hernia phenotypes," PLOS ONE, Public Library of Science, vol. 17(12), pages 1-27, December.
    • Handle: RePEc:plo:pone00:0272261
    DOI: 10.1371/journal.pone.0272261
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    References listed on IDEAS

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    1. Akira Wiberg & Michael Ng & Annina B. Schmid & Robert W. Smillie & Georgios Baskozos & Michael V. Holmes & K. Künnapuu & R. Mägi & David L. Bennett & Dominic Furniss, 2019. "A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    2. Eric Jorgenson & Nadja Makki & Ling Shen & David C. Chen & Chao Tian & Walter L. Eckalbar & David Hinds & Nadav Ahituv & Andrew Avins, 2015. "A genome-wide association study identifies four novel susceptibility loci underlying inguinal hernia," Nature Communications, Nature, vol. 6(1), pages 1-9, December.
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