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Psychological interventions to prevent relapse in anxiety and depression: A systematic review and meta-analysis

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  • Esther Krijnen-de Bruin
  • Willemijn Scholten
  • Anna Muntingh
  • Otto Maarsingh
  • Berno van Meijel
  • Annemieke van Straten
  • Neeltje Batelaan

Abstract

Objectives: The aim of this review is to establish the effectiveness of psychological relapse prevention interventions, as stand-alone interventions and in combination with maintenance antidepressant treatment (M-ADM) or antidepressant medication (ADM) discontinuation for patients with remitted anxiety disorders or major depressive disorders (MDD). Methods: A systematic review and a meta-analysis were conducted. A literature search was conducted in PubMed, PsycINFO and Embase for randomised controlled trials (RCTs) comparing psychological relapse prevention interventions to treatment as usual (TAU), with the proportion of relapse/recurrence and/or time to relapse/recurrence as outcome measure. Results: Thirty-six RCTs were included. During a 24-month period, psychological interventions significantly reduced risk of relapse/recurrence for patients with remitted MDD (RR 0.76, 95% CI: 0.68–0.86, p

Suggested Citation

  • Esther Krijnen-de Bruin & Willemijn Scholten & Anna Muntingh & Otto Maarsingh & Berno van Meijel & Annemieke van Straten & Neeltje Batelaan, 2022. "Psychological interventions to prevent relapse in anxiety and depression: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 17(8), pages 1-20, August.
    • Handle: RePEc:plo:pone00:0272200
    DOI: 10.1371/journal.pone.0272200
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