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Apelin and its ratio to lipid factors are associated with cardiovascular diseases: A systematic review and meta-analysis

Author

Listed:
  • Hamed Akbari
  • Mahnaz Hosseini-Bensenjan
  • Sarvenaz Salahi
  • Fatemeh Moazzen
  • Hamid Aria
  • Alireza Manafi
  • Saeed Hosseini
  • Maryam Niknam
  • Gholamreza Asadikaram

Abstract

Background: The present systematic review and meta-analysis aimed to ascertain if the circulating levels of apelin, as an important regulator of the cardiovascular homeostasis, differ in patients with cardiovascular diseases (CVDs) and controls. Methods: A comprehensive search was performed in electronic databases including PubMed, Scopus, EMBASE, and Web of Science to identify the studies addressing apelin in CVD up to April 5, 2021. Due to the presence of different units to measure the circulating levels of apelin across the included studies, they expressed the standardized mean difference (SMD) and their 95% confidence interval (CI) as summary effect size. A random-effects model comprising DerSimonian and Laird method was used to pool SMDs. Results: Twenty-four articles (30 studies) comprised of 1793 cases and 1416 controls were included. Pooled results obtained through random-effects model indicated that apelin concentrations in the cases’ blood samples were significantly lower than those of the control groups (SMD = -0.72, 95% CI: -1.25, -0.18, P = 0.009; I2 = 97.3%, P

Suggested Citation

  • Hamed Akbari & Mahnaz Hosseini-Bensenjan & Sarvenaz Salahi & Fatemeh Moazzen & Hamid Aria & Alireza Manafi & Saeed Hosseini & Maryam Niknam & Gholamreza Asadikaram, 2022. "Apelin and its ratio to lipid factors are associated with cardiovascular diseases: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 17(8), pages 1-14, August.
    • Handle: RePEc:plo:pone00:0271899
    DOI: 10.1371/journal.pone.0271899
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