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The effect of Cyclophilin D depletion on liver regeneration following associating liver partition and portal vein ligation for staged hepatectomy

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  • Noemi Daradics
  • Gergo Horvath
  • Laszlo Tretter
  • Agnes Paal
  • Andras Fulop
  • Andras Budai
  • Attila Szijarto

Abstract

Aim: Associating Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS) is a modification of two-stage hepatectomy profitable for patients with inoperable hepatic tumors by standard techniques. Unfortunately, initially poor postoperative outcome was associated with ALPPS, in which mitochondrial dysfunction played an essential role. Inhibition of cyclophilins has been already proposed to be efficient as a mitochondrial therapy in liver diseases. To investigate the effect of Cyclophilin D (CypD) depletion on mitochondrial function, biogenesis and liver regeneration following ALPPS a CypD knockout (KO) mice model was created. Methods: Male wild type (WT) (n = 30) and CypD KO (n = 30) mice underwent ALPPS procedure. Animals were terminated pre-operatively and 24, 48, 72 or 168 h after the operation. Mitochondrial functional studies and proteomic analysis were performed. Regeneration rate and mitotic activity were assessed. Results: The CypD KO group displayed improved mitochondrial function, as both ATP production (P

Suggested Citation

  • Noemi Daradics & Gergo Horvath & Laszlo Tretter & Agnes Paal & Andras Fulop & Andras Budai & Attila Szijarto, 2022. "The effect of Cyclophilin D depletion on liver regeneration following associating liver partition and portal vein ligation for staged hepatectomy," PLOS ONE, Public Library of Science, vol. 17(7), pages 1-15, July.
    • Handle: RePEc:plo:pone00:0271606
    DOI: 10.1371/journal.pone.0271606
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