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Predictive significance of joint plasma fibrinogen and urinary alpha-1 microglobulin-creatinine ratio in patients with diabetic kidney disease

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  • Lianlian Pan
  • Mingyi Wo
  • Chan Xu
  • Yan Wu
  • Yali Ye
  • Fan Han
  • Xianming Fei
  • Fengjiao Zhu

Abstract

Background: Although many biomarkers have high diagnostic and predictive power for diabetic kidney disease (DKD), less studies were performed for the predictive assessment in DKD and its progression with combined blood and urinary biomarkers. This study aims to explore the predictive significance of joint plasma fibrinogen (FIB) concentration and urinary alpha-1 microglobulin-creatinine (α1-MG/CR) ratio in DKD. Methods: A total of 234 patients with type 2 diabetes were enrolled, and their clinical and laboratory data were retrospectively assessed. A ROC curve analysis was performed to evaluate the power of plasma FIB and urinary α1-MG/CR ratio for identifying DKD and advanced DKD, respectively. The predictive power for DKD and advanced DKD was analyzed by regression analysis. Results: Plasma FIB and urinary α1-MG/CR levels were higher in patients with DKD than with pure T2D (p 0.05). The multivariate-adjusted ORs for joint FIB and α1-MG/CR at the cut-off values were 214.500 (95%CI: 58.054–792.536) and 3.252 (95%CI: 1.040–10.175) (p

Suggested Citation

  • Lianlian Pan & Mingyi Wo & Chan Xu & Yan Wu & Yali Ye & Fan Han & Xianming Fei & Fengjiao Zhu, 2022. "Predictive significance of joint plasma fibrinogen and urinary alpha-1 microglobulin-creatinine ratio in patients with diabetic kidney disease," PLOS ONE, Public Library of Science, vol. 17(7), pages 1-14, July.
    • Handle: RePEc:plo:pone00:0271181
    DOI: 10.1371/journal.pone.0271181
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