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Genetic polymorphisms associated with susceptibility to COVID-19 disease and severity: A systematic review and meta-analysis

Author

Listed:
  • Cristine Dieter
  • Letícia de Almeida Brondani
  • Cristiane Bauermann Leitão
  • Fernando Gerchman
  • Natália Emerim Lemos
  • Daisy Crispim

Abstract

Although advanced age and presence of comorbidities significantly impact the variation observed in the clinical symptoms of COVID-19, it has been suggested that genetic variants may also be involved in the disease. Thus, the aim of this study was to perform a systematic review with meta-analysis of the literature to identify genetic polymorphisms that are likely to contribute to COVID-19 pathogenesis. Pubmed, Embase and GWAS Catalog repositories were systematically searched to retrieve articles that investigated associations between polymorphisms and COVID-19. For polymorphisms analyzed in 3 or more studies, pooled OR with 95% CI were calculated using random or fixed effect models in the Stata Software. Sixty-four eligible articles were included in this review. In total, 8 polymorphisms in 7 candidate genes and 74 alleles of the HLA loci were analyzed in 3 or more studies. The HLA-A*30 and CCR5 rs333Del alleles were associated with protection against COVID-19 infection, while the APOE rs429358C allele was associated with risk for this disease. Regarding COVID-19 severity, the HLA-A*33, ACE1 Ins, and TMPRSS2 rs12329760T alleles were associated with protection against severe forms, while the HLA-B*38, HLA-C*6, and ApoE rs429358C alleles were associated with risk for severe forms of COVID-19. In conclusion, polymorphisms in the ApoE, ACE1, TMPRSS2, CCR5, and HLA loci appear to be involved in the susceptibility to and/or severity of COVID-19.

Suggested Citation

  • Cristine Dieter & Letícia de Almeida Brondani & Cristiane Bauermann Leitão & Fernando Gerchman & Natália Emerim Lemos & Daisy Crispim, 2022. "Genetic polymorphisms associated with susceptibility to COVID-19 disease and severity: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 17(7), pages 1-23, July.
    • Handle: RePEc:plo:pone00:0270627
    DOI: 10.1371/journal.pone.0270627
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