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Spatiotemporal cluster patterns of hand, foot, and mouth disease at the province level in mainland China, 2011–2018

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  • Yuanzhe Wu
  • Tingwei Wang
  • Mingyi Zhao
  • Shumin Dong
  • Shiwen Wang
  • Jingcheng Shi

Abstract

Although three monovalent EV-A71 vaccines have been launched in mainland China since 2016, hand, foot, and mouth disease (HFMD) still causes a considerable disease burden in China. Vaccines’ use may change the epidemiological characters of HFMD. Spatial autocorrelation analysis and space-time scan statistics analysis were used to explore the spatiotemporal distribution pattern of this disease at the provincial level in mainland China. The effects of meteorological factors, socio-economic factors, and health resources on HFMD incidence were analyzed using Geodetector. Interrupted time series (ITS) was used to analyze the impact of the EV-A71 vaccine on the incidence of HFMD. This study found that the median annual incidence of HFMD was 153.78 per 100,000 (ranging from 120.79 to 205.06) in mainland China from 2011 to 2018. Two peaks of infections were observed per year. Children 5 years and under were the main morbid population. The spatial distribution of HFMD was presented a significant clustering pattern in each year (P

Suggested Citation

  • Yuanzhe Wu & Tingwei Wang & Mingyi Zhao & Shumin Dong & Shiwen Wang & Jingcheng Shi, 2022. "Spatiotemporal cluster patterns of hand, foot, and mouth disease at the province level in mainland China, 2011–2018," PLOS ONE, Public Library of Science, vol. 17(8), pages 1-25, August.
    • Handle: RePEc:plo:pone00:0270061
    DOI: 10.1371/journal.pone.0270061
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    References listed on IDEAS

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    1. Chao Wang & Xia Li & Yingjie Zhang & Qin Xu & Fangfang Huang & Kai Cao & Lixin Tao & Jin Guo & Qi Gao & Wei Wang & Liqun Fang & Xiuhua Guo, 2016. "Spatiotemporal Cluster Patterns of Hand, Foot, and Mouth Disease at the County Level in Mainland China, 2008-2012," PLOS ONE, Public Library of Science, vol. 11(1), pages 1-13, January.
    2. Bin Zhu & Yang Fu & Jinlin Liu & Ying Mao, 2017. "Notifiable Sexually Transmitted Infections in China: Epidemiologic Trends and Spatial Changing Patterns," Sustainability, MDPI, vol. 9(10), pages 1-16, October.
    3. Jijun Zhao & Xinmin Li, 2016. "Determinants of the Transmission Variation of Hand, Foot and Mouth Disease in China," PLOS ONE, Public Library of Science, vol. 11(10), pages 1-14, October.
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