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Association between urinary biomarkers MMP-7/TIMP-2 and reduced renal function in children with ureteropelvic junction obstruction

Author

Listed:
  • Hsin-Hsiao S Wang
  • Patricia S Cho
  • Hui Zhi
  • Stephen A Kostel
  • Shannon DiMartino
  • Adelle M Dagher
  • Kylie H Davis
  • Lily D Cabour
  • Ashley Shimmel
  • James Lee
  • John W Froehlich
  • David Zurakowski
  • Marsha A Moses
  • Richard S Lee

Abstract

Importance: Extracellular matrix proteins and enzymes involved in degradation have been found to be associated with tissue fibrosis and ureteropelvic junction obstruction (UPJO). In this study we developed a promising urinary biomarker model which can identify reduced renal function in UPJ obstruction patients. This can potentially serve as a non-invasive way to enhance surgical decision making for patients and urologists. Objective: We sought to develop a predictive model to identify UPJO patients at risk for reduced renal function. Design: Prospective cohort study Setting: Pre-operative urine samples were collected in a prospectively enrolled UPJO biomarker registry at our institution. Urinary MMP-2, MMP-7, TIMP-2, and NGAL were measured as well as clinical characteristics including hydronephrosis grade, differential renal function, t1/2, and UPJO etiology. Participants: Children who underwent pyeloplasty for UPJO Main outcome measurement: Primary outcome was reduced renal function defined as MAG3 function

Suggested Citation

  • Hsin-Hsiao S Wang & Patricia S Cho & Hui Zhi & Stephen A Kostel & Shannon DiMartino & Adelle M Dagher & Kylie H Davis & Lily D Cabour & Ashley Shimmel & James Lee & John W Froehlich & David Zurakowski, 2022. "Association between urinary biomarkers MMP-7/TIMP-2 and reduced renal function in children with ureteropelvic junction obstruction," PLOS ONE, Public Library of Science, vol. 17(7), pages 1-11, July.
    • Handle: RePEc:plo:pone00:0270018
    DOI: 10.1371/journal.pone.0270018
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