IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0269969.html
   My bibliography  Save this article

Real-world evidence on levodopa dose escalation in patients with Parkinson’s disease treated with istradefylline

Author

Listed:
  • Nobutaka Hattori
  • Daijiro Kabata
  • Shinji Asada
  • Tomoyuki Kanda
  • Takanobu Nomura
  • Ayumi Shintani
  • Akihisa Mori

Abstract

Objective: Istradefylline, a selective adenosine A2A receptor antagonist, is indicated in the US and Japan as adjunctive treatment to levodopa/decarboxylase inhibitors in adults with Parkinson’s disease (PD) experiencing OFF time. This study aimed to observe patterns of dose escalation of levodopa over time in patients initiated on istradefylline. Methods: Using Japanese electronic health record data, interrupted time series analyses were used to compare levodopa daily dose (LDD, mg/day) gradients in patients before and after initiation of istradefylline. Data were analyzed by period relative to istradefylline initiation (Month 1): pre-istradefylline (Months -72 to 0), early istradefylline (Months 1 to 24), and late istradefylline (Months 25 to 72). Subgroup analyses included LDD before istradefylline initiation (

Suggested Citation

  • Nobutaka Hattori & Daijiro Kabata & Shinji Asada & Tomoyuki Kanda & Takanobu Nomura & Ayumi Shintani & Akihisa Mori, 2023. "Real-world evidence on levodopa dose escalation in patients with Parkinson’s disease treated with istradefylline," PLOS ONE, Public Library of Science, vol. 18(12), pages 1-13, December.
    • Handle: RePEc:plo:pone00:0269969
    DOI: 10.1371/journal.pone.0269969
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0269969
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0269969&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0269969?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0269969. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.