IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0269558.html
   My bibliography  Save this article

The risks of RELN polymorphisms and its expression in the development of otosclerosis

Author

Listed:
  • Saurabh Priyadarshi
  • Kirtal Hansdah
  • Neha Singh
  • Amal Bouzid
  • Chinmay Sundar Ray
  • Khirod Chandra Panda
  • Narayan Chandra Biswal
  • Ashim Desai
  • Jyotish Chandra Choudhury
  • Adel Tekari
  • Saber Masmoudi
  • Puppala Venkat Ramchander

Abstract

Otosclerosis (OTSC) is the primary form of conductive hearing loss characterized by abnormal bone remodelling within the otic capsule of the human middle ear. A genetic association of the RELN SNP rs3914132 with OTSC has been identified in European population. Previously, we showed a trend towards association of this polymorphism with OTSC and identified a rare variant rs74503667 in a familial case. Here, we genotyped these variants in an Indian cohort composed of 254 OTSC cases and 262 controls. We detected a significant association of rs3914132 with OTSC (OR = 0.569, 95%CI = 0.386–0.838, p = 0.0041). To confirm this finding, we completed a meta-analysis which revealed a significant association of the rs3914132 polymorphism with OTSC (Z = 6.707, p

Suggested Citation

  • Saurabh Priyadarshi & Kirtal Hansdah & Neha Singh & Amal Bouzid & Chinmay Sundar Ray & Khirod Chandra Panda & Narayan Chandra Biswal & Ashim Desai & Jyotish Chandra Choudhury & Adel Tekari & Saber Mas, 2022. "The risks of RELN polymorphisms and its expression in the development of otosclerosis," PLOS ONE, Public Library of Science, vol. 17(6), pages 1-20, June.
    • Handle: RePEc:plo:pone00:0269558
    DOI: 10.1371/journal.pone.0269558
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0269558
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0269558&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0269558?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0269558. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.