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Heart rate variability in hypothyroid patients: A systematic review and meta-analysis

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  • Valentin Brusseau
  • Igor Tauveron
  • Reza Bagheri
  • Ukadike Chris Ugbolue
  • Valentin Magnon
  • Valentin Navel
  • Jean-Baptiste Bouillon-Minois
  • Frederic Dutheil

Abstract

Introduction: Hypothyroidism may be associated with changes in the autonomic regulation of the cardiovascular system, which may have clinical implications. Objective: To conduct a systematic review and meta-analysis on the impact of hypothyroidism on HRV. Materials and methods: PubMed, Cochrane, Embase and Google Scholar were searched until 20 August 2021 for articles reporting HRV parameters in untreated hypothyroidism and healthy controls. Random-effects meta-analysis were stratified by degree of hypothyroidism for each HRV parameters: RR intervals (or normal to normal-NN intervals), SDNN (standard deviation of RR intervals), RMSSD (square root of the mean difference of successive RR intervals), pNN50 (percentage of RR intervals with >50ms variation), total power (TP), LFnu (low-frequency normalized unit), HFnu (high-frequency), VLF (very low frequency), and LF/HF ratio. Results: We included 17 studies with 11438 patients: 1163 hypothyroid patients and 10275 healthy controls. There was a decrease in SDNN (effect size = -1.27, 95% CI -1.72 to -0.83), RMSSD (-1.66, -2.32 to -1.00), pNN50 (-1.41, -1.98 to -0.84), TP (-1.55, -2.1 to -1.00), HFnu (-1.21, -1.78 to -0.63) with an increase in LFnu (1.14, 0.63 to 1.66) and LF/HF ratio (1.26, 0.71 to 1.81) (p

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  • Valentin Brusseau & Igor Tauveron & Reza Bagheri & Ukadike Chris Ugbolue & Valentin Magnon & Valentin Navel & Jean-Baptiste Bouillon-Minois & Frederic Dutheil, 2022. "Heart rate variability in hypothyroid patients: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 17(6), pages 1-18, June.
    • Handle: RePEc:plo:pone00:0269277
    DOI: 10.1371/journal.pone.0269277
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