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Alprostadil for hypertensive nephropathy: A systematic review and meta-analysis of randomized controlled trials

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  • Hongfang Fu
  • Weiwei Hou
  • Yang Zhang
  • Xiaoyu Hu

Abstract

We performed a meta-analysis to evaluate the efficacy of alprostadil in the treatment of hypertensive nephropathy. Seven online databases (PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure [CNKI] database, Wanfang Data Knowledge Service Platform, VIP Information Resource Integration Service Platform [cqVIP], and China Biology Medicine Disc [SinoMed]) were searched from inception to January 31, 2022, and a set of clinical indicators for hypertensive nephropathy was selected. The main indicators were 24-h urinary protein, serum creatinine, endogenous serum creatinine clearance rate, blood urea nitrogen, cystatin C, and mean arterial pressure. The methodological quality of the included trials was analyzed using a risk of bias assessment according to the Cochrane Manual guidelines, and a meta-analysis was performed. A random-effects model was implemented to pool the results. A total of 20 randomized controlled trials involving 1441 patients with hypertensive nephropathy were included in this review. Our findings showed that alprostadil had a positive effect on 24-h urinary protein (mean difference [MD] = −0.79, 95% confidence interval [CI] [−1.16, −0.42], P

Suggested Citation

  • Hongfang Fu & Weiwei Hou & Yang Zhang & Xiaoyu Hu, 2022. "Alprostadil for hypertensive nephropathy: A systematic review and meta-analysis of randomized controlled trials," PLOS ONE, Public Library of Science, vol. 17(5), pages 1-17, May.
    • Handle: RePEc:plo:pone00:0269111
    DOI: 10.1371/journal.pone.0269111
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