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The role and mechanism of tetramethylpyrazine for atherosclerosis in animal models: A systematic review and meta-analysis

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  • SiJin Li
  • Ping Liu
  • XiaoTeng Feng
  • YiRu Wang
  • Min Du
  • JiaRou Wang

Abstract

Background: Atherosclerosis(AS) is widely recognized as a risk factor for incident cardiovascular and cerebrovascular diseases. Tetramethylpyrazine (TMP) is the active ingredient of Ligusticum wallichii that possesses a variety of biological activities against atherosclerosis. Objective: This systematic review and meta-analysis sought to study the impact of and mechanism of tetramethylpyrazine for atherosclerosis in animal models. Methods: A systematic search was conducted of PubMed, Embase, Cochrane Library, Web of Science database, Chinese Biomedical (CBM) database, China National Knowledge Infrastructure (CNKI), WanFang data, and Vip Journal Integration Platform, covering the period from the respective start date of each database to December 2021. We used SYRCLE’s 10-item checklist and Rev-Man 5.3 software to analyze the data and the risk of bias. Results: Twelve studies, including 258 animals, met the inclusion criteria. Compared with the control group, TMP significantly reduced aortic atherosclerotic lesion area, and induced significant decreases in levels of TC (SMD = ‐2.67, 95% CI -3.68 to -1.67, P

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  • SiJin Li & Ping Liu & XiaoTeng Feng & YiRu Wang & Min Du & JiaRou Wang, 2022. "The role and mechanism of tetramethylpyrazine for atherosclerosis in animal models: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 17(5), pages 1-19, May.
    • Handle: RePEc:plo:pone00:0267968
    DOI: 10.1371/journal.pone.0267968
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