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The efficiency and safety of alendronate versus teriparatide for treatment glucocorticoid-induced osteoporosis: A meta-analysis and systematic review of randomized controlled trials

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  • Zhi-Ming Liu
  • Min Zhang
  • Yuan Zong
  • Ding Zhang
  • Zhu-Bin Shen
  • Xiao-Qing Guan
  • Fei Yin

Abstract

Background: Glucocorticoid-induced osteoporosis (GIOP) is the most common secondary osteoporosis, alendronate (ALE) and teriparatide (TPTD) are widely used in the treatment of GIOP. However, which of these two drugs has a better curative effect needs the support of evidence-based medicine. Methods: We searched PubMed, Embase, Cochrane Library, Web of Science, and Google Scholar for randomized controlled trials of ALE and TPTD in the treatment of glucocorticoid-induced osteoporosis until February 2022. These patients included in the study took glucocorticoid doses greater than 7.5 mg/d for more than 3 months before treatment with ALE and TPTD. The risk ratio (RR) and its 95% confidence interval (CI) are used as the influence index of discontinuous data, and the standardized mean difference (SMD) and its 95% CI are used as the influence index of continuous data. Results: A total of 4102 patients were enrolled in all 5 studies that met the admission criteria. We found that compared with ALE, TPTD could reduce the rate of new vertebral fracture (RR = 0.13, 95% CI: 0.05–0.34, P

Suggested Citation

  • Zhi-Ming Liu & Min Zhang & Yuan Zong & Ding Zhang & Zhu-Bin Shen & Xiao-Qing Guan & Fei Yin, 2022. "The efficiency and safety of alendronate versus teriparatide for treatment glucocorticoid-induced osteoporosis: A meta-analysis and systematic review of randomized controlled trials," PLOS ONE, Public Library of Science, vol. 17(5), pages 1-15, May.
    • Handle: RePEc:plo:pone00:0267706
    DOI: 10.1371/journal.pone.0267706
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