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Spectral-domain OCT measurements in obesity: A systematic review and meta-analysis

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  • Mohammad Amin Salehi
  • Amirali Karimi
  • Soheil Mohammadi
  • J Fernando Arevalo

Abstract

Background: Previous studies proposed possible applications of spectral-domain optical coherence tomography (SD-OCT) measurements in prognosticating pathologies observed in overweight/obesity, including ocular, vascular, and neurologic consequences. Therefore, we conducted a systematic review and meta-analysis to investigate the changes in the in SD-OCT measurements of the patients with higher body mass index (BMI) compared to normal weight individuals. Materials and methods: We conducted a systematic search on PubMed, Scopus, and Embase. The search results underwent two-phase title/abstract and full-text screenings. We then analyzed SD-OCT measurements differences in patients with high BMI and controls, and performed meta-regression, sub-group analysis, quality assessment, and publication bias assessment. The measurements included macular thickness, cup to disc ratio, ganglion cell-inner plexiform layer (GC-IPL) and its sub-sectors, RNFL and peripapillary RNFL (pRNFL) and their sub-layers, and choroidal thickness and its sub-sectors. Results: 19 studies were included in this meta-analysis accounting for 1813 individuals, 989 cases and 824 controls. There was an overall trend towards decreased thickness in high BMI patients, but only two measurements reached statistical significance: temporal retinal nerve fiber layer (RNFL) (Standardized mean difference (SMD): -0.33, 95% confidence interval (CI): -0.53 to -0.14, p

Suggested Citation

  • Mohammad Amin Salehi & Amirali Karimi & Soheil Mohammadi & J Fernando Arevalo, 2022. "Spectral-domain OCT measurements in obesity: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 17(4), pages 1-24, April.
    • Handle: RePEc:plo:pone00:0267495
    DOI: 10.1371/journal.pone.0267495
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