IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0267108.html
   My bibliography  Save this article

The clinical value of miRNA-21 in cervical cancer: A comprehensive investigation based on microarray datasets

Author

Listed:
  • Zhi-Min Deng
  • Gan-Hong Chen
  • Fang-Fang Dai
  • Shi-Yi Liu
  • Dong-Yong Yang
  • An-Yu Bao
  • Yan-Xiang Cheng

Abstract

Previous work has demonstrated that the expression of microRNA-21 (miR-21) is implicated in cervical cancer (CC). However, little is known regarding its associations with clinical parameters. We first conducted a meta-analysis using data from Gene Expression Omnibus (GEO) microarrays and The Cancer Genome Atlas (TCGA). Then, enrichment analysis and hub gene screening were performed by bioinformatic methods. Finally, the role of the screened target genes in CC was explored. According to the meta-analysis, the expression of miR-21 in cancer tissues was higher than in adjacent nontumor tissues (P

Suggested Citation

  • Zhi-Min Deng & Gan-Hong Chen & Fang-Fang Dai & Shi-Yi Liu & Dong-Yong Yang & An-Yu Bao & Yan-Xiang Cheng, 2022. "The clinical value of miRNA-21 in cervical cancer: A comprehensive investigation based on microarray datasets," PLOS ONE, Public Library of Science, vol. 17(4), pages 1-13, April.
    • Handle: RePEc:plo:pone00:0267108
    DOI: 10.1371/journal.pone.0267108
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0267108
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0267108&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0267108?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0267108. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.