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Safety and efficacy of colchicine in COVID-19 patients: A systematic review and meta-analysis of randomized control trials

Author

Listed:
  • Farah Yasmin
  • Hala Najeeb
  • Abdul Moeed
  • Wardah Hassan
  • Mahima Khatri
  • Muhammad Sohaib Asghar
  • Ahmed Kunwer Naveed
  • Waqas Ullah
  • Salim Surani

Abstract

Background: Colchicine has been used an effective anti-inflammatory drug to treat gout diseases. Owing to its pharmacodynamic of inhibiting interleukins, it has been repurposed to target the cytokine storm post-SARS-CoV-2 invasion. The goal of this meta-analysis was to evaluate the safety profile of colchicine in COVID-19 patients using the gold-standard randomised-control trials. Methods: Electronic databases (Pubmed, Google Scholar, and Cochrane) were systematically searched until June 2021 and RCTs were extracted. Outcomes of interest included all-cause mortality, COVID-19 severity, mechanical ventilation, C-reactive protein and D-dimer levels. Using a random-effects model, dichotomous outcomes were pooled using odds ratios (OR) through the generic inverse variance formula while weighted mean differences were calculated using the Wan’s method. P-values

Suggested Citation

  • Farah Yasmin & Hala Najeeb & Abdul Moeed & Wardah Hassan & Mahima Khatri & Muhammad Sohaib Asghar & Ahmed Kunwer Naveed & Waqas Ullah & Salim Surani, 2022. "Safety and efficacy of colchicine in COVID-19 patients: A systematic review and meta-analysis of randomized control trials," PLOS ONE, Public Library of Science, vol. 17(4), pages 1-13, April.
    • Handle: RePEc:plo:pone00:0266245
    DOI: 10.1371/journal.pone.0266245
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