IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0265903.html
   My bibliography  Save this article

Clinical features of obscure gastrointestinal bleeding undergoing capsule endoscopy: A retrospective cohort study

Author

Listed:
  • Yuga Komaki
  • Shuji Kanmura
  • Kazuki Yutsudo
  • Kosuke Kuwazuru
  • Fukiko Komaki
  • Akihito Tanaka
  • Hidehito Maeda
  • Shiho Arima
  • Shiroh Tanoue
  • Fumisato Sasaki
  • Shinichi Hashimoto
  • Masahisa Horiuchi
  • Akio Ido

Abstract

Background: Capsule endoscopy has been widely used to investigate obscure gastrointestinal bleeding (OGIB) in the small intestine since its approval in 2001. However, the clinical features of OGIB remain unclear. Aim: We retrospectively examined the clinical features and risk factors of OGIB in patients who underwent capsule endoscopy in our hospital. Methods: We included 420 of the 431 patients who underwent capsule endoscopy from June 2014 to May 2021, in whom the small intestine could be observed. We retrospectively compared the clinical features and treatment of OGIB cases, with or without active small bowel bleeding (n = 173), with other cases (n = 247). Patient sex, age, diabetes mellitus, and heart failure histories were matched for the analysis. Results: The male/female ratio was 247/173 and the average age was 51.54 years. In multivariate analysis, the use of direct oral anticoagulants was significant (P = 0.016), and vascular lesions (P = 0.018) were observed in OGIB cases. When OGIB cases with and without active small bowel bleeding were compared, serum albumin level was lower in cases with active bleeding (P = 0.031). When treatment of OGIB cases were compared, those without vascular lesions could be treated conservatively (P = 0.0047). In the 1:1 propensity score matching analysis, serum creatinine level was elevated in cases of active bleeding (P = 0.029), and cases without vascular lesions were treated conservatively (P = 0.010). Conclusions: Use of direct oral anticoagulants is frequently associated with OGIB. OGIB patients without vascular lesions may be treated conservatively.

Suggested Citation

  • Yuga Komaki & Shuji Kanmura & Kazuki Yutsudo & Kosuke Kuwazuru & Fukiko Komaki & Akihito Tanaka & Hidehito Maeda & Shiho Arima & Shiroh Tanoue & Fumisato Sasaki & Shinichi Hashimoto & Masahisa Horiuch, 2022. "Clinical features of obscure gastrointestinal bleeding undergoing capsule endoscopy: A retrospective cohort study," PLOS ONE, Public Library of Science, vol. 17(3), pages 1-16, March.
    • Handle: RePEc:plo:pone00:0265903
    DOI: 10.1371/journal.pone.0265903
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0265903
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0265903&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0265903?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Gavriel Iddan & Gavriel Meron & Arkady Glukhovsky & Paul Swain, 2000. "Wireless capsule endoscopy," Nature, Nature, vol. 405(6785), pages 417-417, May.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Ernesto De la Paz & Nikhil Harsha Maganti & Alexander Trifonov & Itthipon Jeerapan & Kuldeep Mahato & Lu Yin & Thitaporn Sonsa-ard & Nicolas Ma & Won Jung & Ryan Burns & Amir Zarrinpar & Joseph Wang &, 2022. "A self-powered ingestible wireless biosensing system for real-time in situ monitoring of gastrointestinal tract metabolites," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Rongguo Yan & Xudong Guo, 2013. "Nonlinear fractal dynamics of human colonic pressure activity based upon the box-counting method," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 16(6), pages 660-668, June.
    3. Michael Sey & Brian Yan & Cassandra McDonald & Dan Segal & Joshua Friedland & Klajdi Puka & Vipul Jairath, 2021. "A randomized controlled trial of high volume simethicone to improve visualization during capsule endoscopy," PLOS ONE, Public Library of Science, vol. 16(4), pages 1-11, April.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0265903. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.