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Analysis of bone erosions in rheumatoid arthritis using HR-pQCT: Development of a measurement algorithm and assessment of longitudinal changes

Author

Listed:
  • Kazuteru Shiraishi
  • Ko Chiba
  • Kounosuke Watanabe
  • Nozomi Oki
  • Naoki Iwamoto
  • Shoken Amano
  • Akihiko Yonekura
  • Masato Tomita
  • Masataka Uetani
  • Atsushi Kawakami
  • Makoto Osaki

Abstract

Purpose: The purpose of this study was to establish an algorithm for measuring bone erosions at metacarpophalangeal (MCP) joints using high-resolution peripheral quantitative computed tomography (HR-pQCT), to investigate the precision of measurements, and to assess longitudinal changes in bone erosions among patients with rheumatoid arthritis (RA). Methods: The 2nd and 3rd MCP joints were scanned at a voxel size of 60.7 μm using second-generation HR-pQCT. Bone erosions on MCP joints were identified using a semi-automated algorithm we developed, and each erosion parameter was measured. Measurement reproducibility was evaluated in 19 healthy subjects using intraclass correlation coefficients (ICCs) and root mean square percent coefficient of variance (RMS%CV). Finally, longitudinal changes in bone erosions over a period of 12 months were assessed in 26 patients with RA based on the calculated least significant change (LSC). Results: Reproducibilities for measurement parameters regarding bone erosions with our algorithm were good (all ICCs ≥ 0.98; all RMS%CVs

Suggested Citation

  • Kazuteru Shiraishi & Ko Chiba & Kounosuke Watanabe & Nozomi Oki & Naoki Iwamoto & Shoken Amano & Akihiko Yonekura & Masato Tomita & Masataka Uetani & Atsushi Kawakami & Makoto Osaki, 2022. "Analysis of bone erosions in rheumatoid arthritis using HR-pQCT: Development of a measurement algorithm and assessment of longitudinal changes," PLOS ONE, Public Library of Science, vol. 17(4), pages 1-14, April.
    • Handle: RePEc:plo:pone00:0265833
    DOI: 10.1371/journal.pone.0265833
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