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Efficacy and safety of eplerenone treatment for patients with diabetic nephropathy: A meta-analysis

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  • Honglei Hu
  • Xiaodong Zhao
  • Xingqian Jin
  • Shujuan Wang
  • Wenlong Liang
  • Xiangguo Cong

Abstract

Diabetic nephropathy (DN), which is correlated with an increased risk of cardiovascular disease, significantly elevates the morbidity and mortality of patients with diabetes. Recently, the benefits of mineralocorticoid receptor antagonists in chronic kidney disease (CKD), such as their anti-inflammatory and anti-fibrotic properties, have been discovered. Thus, the present meta-analysis aimed to systematically assess the efficacy and safety of eplerenone treatment in patients with DN. Six electronic databases—PubMed, The Cochrane Library, Embase, Web of Science, CNKI (China National Knowledge Infrastructure), and CBM(Chinese BioMedical Literature Database)—were searched to retrieve randomized controlled trials that assessed eplerenone treatment in patients with DN and were published up to July 31, 2021. Eight randomized controlled trials involving 838 patients were included. Between the eplerenone treatment groups and controls, significant differences were identified in 24-h urine protein levels (mean difference [MD], −19.63 [95% CI, −23.73 to −15.53], P

Suggested Citation

  • Honglei Hu & Xiaodong Zhao & Xingqian Jin & Shujuan Wang & Wenlong Liang & Xiangguo Cong, 2022. "Efficacy and safety of eplerenone treatment for patients with diabetic nephropathy: A meta-analysis," PLOS ONE, Public Library of Science, vol. 17(3), pages 1-16, March.
    • Handle: RePEc:plo:pone00:0265642
    DOI: 10.1371/journal.pone.0265642
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