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A Bayesian network meta-analysis of the primary definitive therapies for locoregionally advanced nasopharyngeal carcinoma: IC+CCRT, CCRT+AC, and CCRT alone

Author

Listed:
  • Zhan-Jie Zhang
  • Liang-Liang Shi
  • Xiao-Hua Hong
  • Bo-Ya Xiao
  • Guo-He Lin
  • Quentin Liu
  • Bi-Cheng Wang

Abstract

Background: The major aim of this Bayesian network analysis was to determine the optimal treatment strategy for locoregionally advanced nasopharyngeal carcinoma (LANPC). Method: We systematically searched databases and extracted data from randomized clinical trials involving LANPC patients randomly assigned to receive induction chemotherapy followed by concurrent chemoradiotherapy (IC+CCRT), CCRT followed by adjuvant chemotherapy (CCRT+AC), or CCRT. Results: In the network analysis, IC+CCRT was significantly better than CCRT alone for 5-year FFS (odds ratio [OR]: 1.63, 95% credible interval [CrI] 1.16–2.29), DMFS (OR: 1.56, 95% CrI 1.08–2.22), and LFRS (OR: 1.62, 95% CrI 1.02–2.59), but not OS (OR: 1.35, 95% CrI 0.92–2.00). Rank probabilities showed that IC+CCRT was ranked the best followed by CCRT+AC and CCRT for all 5-year outcomes. Although compared to IC+CCRT and CCRT, CCRT+AC did not significantly improve survival but had the highest 5-year survival rates. Conclusions: IC+CCRT could be recommended as a front-preferred primary definitive therapy for patients with LANPC.

Suggested Citation

  • Zhan-Jie Zhang & Liang-Liang Shi & Xiao-Hua Hong & Bo-Ya Xiao & Guo-He Lin & Quentin Liu & Bi-Cheng Wang, 2022. "A Bayesian network meta-analysis of the primary definitive therapies for locoregionally advanced nasopharyngeal carcinoma: IC+CCRT, CCRT+AC, and CCRT alone," PLOS ONE, Public Library of Science, vol. 17(3), pages 1-11, March.
    • Handle: RePEc:plo:pone00:0265551
    DOI: 10.1371/journal.pone.0265551
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